As a key functional part, high-strength fasteners play an important role in the function realization and safe operation of mechanical products. The correct use of high-strength fasteners is a link that cannot be ignored in the design and manufacture of mechanical products. At present, there is no unified method for the use of high-strength fasteners, and the practices of different industries and units are different. Therefore, it is necessary to communicate with each other and develop a scientific method of use to guide the design, manufacture, assembly and maintenance of products. Ensure the safe and stable operation of machinery. After researching and testing high-strength fasteners, this article summarizes the general use methods of high-strength fasteners from the aspects of characteristics, application, selection and assembly. Fasteners have a wide variety of specifications, large usage, and a wide range of applications. They are the most common type of standard parts in mechanical products. The reasonable selection of fasteners has also become an important part of the product design process. The correct use of the product directly affects the product's functional realization and safe operation. Compared with general fasteners, the use requirements of high-strength fasteners in product design, manufacturing, assembly, inspection and maintenance are very different. They also play a more critical role in the operation of equipment. Under the situation of diversified development such as large-scale, automation, and intelligence, high-strength fasteners are increasingly used as key functional parts, especially in critical occasions and important parts. At present, in the selection and use of high-strength fasteners, there are still various opinions and insufficient understanding, and it is necessary to do further research. This article mainly discusses the use of high-strength fasteners for mechanical products, and will not discuss the use of high-strength fasteners to replace general fasteners.