Fastener is the most common type of standard parts in mechanical products due to its variety, specification, large usage and wide application. The reasonable selection of fasteners has also become an important link in the process of product design. Whether the fasteners are used correctly or not is directly related to the functional realization and safe operation of the product. Compared with general fasteners, high-strength fasteners have different requirements in product design, manufacturing, assembly, inspection and maintenance, and play a more critical role in the operation of equipment. With the development of mechanical products to large-scale, automatic, intelligent and other diversified situations, the use of high-strength fasteners as key functional parts is increasing, especially in key occasions and important parts. At present, there are still some problems in the selection and use of high-strength fasteners, such as different opinions and insufficient understanding. It is necessary to do further research work. This paper mainly discusses the use methods of high-strength fasteners for mechanical products, and does not discuss the use of high-strength fasteners instead of general fasteners.